Alabama rot or idiopathic cutaneous and renal glomerular vasculopathy (CRGV) is an often fatal condition in dogs. It was first identified in the USA in the 1980s in greyhounds. The initial symptoms are skin lesions on the legs, chest and abdomen followed by renal involvement.
In November 2012 the first cases were identified in the UK. In January 2014, the outbreak in England was identified as having the same or similar histological and clinical findings as Alabama rot, although a wide range of breeds were affected. The disease has continued to spread across England, with a case being reported as far north as North Yorkshire in March 2015. A UK map posted on-line shows confirmed (with post-mortem) and unconfirmed (without post-mortem) cases of Alabama rot since December 2012.
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Signs and symptoms
The disease is characterized by cutaneous and renal changes with the latter being ultimately fatal. As kidney disease progresses animals affected become systemically unwell.
Common symptoms include, but are not limited to:
- Cutaneous lesions involving erythema, erosion, ulceration occurring mainly on extremities such as distal limbs, muzzle and ventrum
- Pyrexia
- Lethargy or malaise
- Anorexia
- Vomiting or retching
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Causes
Some veterinary experts theorize it is a parasite, others theorize it is bacterial. It is more widely believed that Alabama rot is caused by toxins produced by E. coli. Because the exact cause has not been found, developing a vaccine is not possible. The cause of Alabama rot in the UK is under study as of 2013 at Anderson Moores Veterinary Specialists in Winchester, Hampshire. A podcast on Alabama rot was published in April 2014 by the Royal Veterinary College. As of February 2015 the Forestry Commission England will only publish specific site location details if "cases are confirmed as CRGV and a scientific connection to the dogs walked on the site is made".
A comprehensive report on CRGV was published in March 2015 by the British Veterinary Association, concluding that it is a disease of unknown cause "carrying a poor prognosis when azotaemia develops".
Treatments
Treatment is primarily symptomatic involving wound management of skin lesions and aggressive supportive therapy when renal compromise occurs. Some UK dogs with Alabama rot have been successfully treated since 2013. A webinar on Alabama rot by the Royal Veterinary College on 11 February 2015 was tutored by David Walker of Anderson Moores Veterinary Specialists.
Epidemiology
The number of cases in the US is not known, but a Hampshire veterinary practice reported on 24 March 2015 that there had been 103 suspected cases in the UK, including 52 deaths confirmed by postmortem examination.
Source of the article : Wikipedia
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